📅 29 April 2026⏱ 10 min read🔬 Clinical reference: ADA 2025, NICE NG28
If your blood test includes HbA1c — and most standard panels do — you've probably glanced at the number and wondered what it actually tells you. It's one of the most clinically important markers in the whole panel. Here's everything you need to know, in plain English.
What is HbA1c and what does it measure?
HbA1c stands for glycated haemoglobin. It's a measure of how much glucose has attached itself to the haemoglobin in your red blood cells over the previous two to three months.
Here's the key idea: glucose is "sticky." When there's more of it circulating in your blood, more of it attaches to haemoglobin. Because red blood cells live for roughly 90 days, your HbA1c reading gives a rolling three-month picture of your average blood sugar levels — rather than just a snapshot of what your glucose was doing at the moment the blood was taken.
📌 Key concept
Unlike a fasting glucose test (which tells you what your blood sugar is right now), HbA1c tells you what your average blood sugar has been over the past 2–3 months. That's why it's so much harder to "cheat" — eating well the day before your test won't move it.
Fig 1. Glucose molecules attach to haemoglobin in red blood cells throughout their 90-day lifespan. The HbA1c test measures the total proportion of glycated cells — giving a long-run average.
Understanding the reference ranges
HbA1c is measured as a percentage (%) in the UK and US, or as mmol/mol (the IFCC unit used across much of Europe). Your lab report may show one or both. They measure the same thing — just expressed differently.
HbA1c (%)
HbA1c (mmol/mol)
Classification
Status
Below 5.7%
Below 39 mmol/mol
Normal
✓ Optimal
5.7 – 6.4%
39 – 47 mmol/mol
Prediabetes
⚠ Watch
6.5% and above
48 mmol/mol and above
Type 2 Diabetes threshold
✕ Act
⚠ Important
A single HbA1c result in the diabetic range should be confirmed with a repeat test on a different day before a diagnosis is made, unless symptoms of diabetes are also present. This is standard clinical practice — not a reason to panic.
Fig 2. The standard HbA1c reference ranges used by the American Diabetes Association (ADA) and NICE. Values are percentages (NGSP/DCCT standard); IFCC equivalents in mmol/mol are shown below the scale.
Why HbA1c matters more than a fasting glucose
A fasting blood glucose test gives you a point-in-time reading. Stress, a bad night's sleep, or eating slightly outside your fasting window can all move it. HbA1c doesn't care about any of that — it reflects what's actually been happening in your bloodstream over months.
This makes HbA1c especially useful for:
Detecting prediabetes early — before fasting glucose has moved out of range
Monitoring blood sugar control in people already diagnosed with diabetes
Tracking the effect of lifestyle changes — diet, exercise, weight loss — over a 3–6 month period
Assessing cardiovascular risk, since elevated HbA1c is an independent risk factor for heart disease even below the diabetes threshold
See your HbA1c in context
VitalMetrics AI cross-references your HbA1c against your other metabolic markers — fasting glucose, insulin resistance proxies, lipids — and gives you a full picture, not just a single number.
HbA1c is robust, but it's not perfect. Several conditions can cause it to read falsely high or falsely low — which is why your doctor should interpret it alongside your full clinical picture.
Things that can cause a falsely high HbA1c
Iron deficiency anaemia (red blood cells live longer, accumulating more glucose)
Vitamin B12 or folate deficiency
Kidney disease (uraemia can affect the test)
Splenectomy (removal of the spleen)
Things that can cause a falsely low HbA1c
Haemolytic anaemia (red blood cells are destroyed faster, so less time to accumulate glucose)
Haemoglobin variants (e.g., sickle cell trait) — certain lab methods may be unreliable
Recent blood transfusion
Pregnancy (blood volume changes affect the reading)
📌 Note
If you have any of the above conditions, your doctor may prefer to monitor blood sugar using fasting glucose or a glucose tolerance test instead of relying solely on HbA1c.
Fig 3. Medical conditions that can cause HbA1c to read inaccurately. Always flag these to your doctor so they can choose the most appropriate blood sugar monitoring method for you.
How to lower your HbA1c
If your HbA1c has come back in the prediabetes range — or higher than it was last time — the good news is that it is genuinely modifiable. Unlike some markers, you can move HbA1c meaningfully with sustained lifestyle change. The ADA estimates that intensive lifestyle intervention can reduce progression from prediabetes to type 2 diabetes by around 58%.
Dietary changes with the strongest evidence
Reduce refined carbohydrates and added sugars — white bread, pastries, sugary drinks, and ultra-processed foods spike blood glucose repeatedly. Replacing them with wholegrains, legumes, and vegetables can lower HbA1c by 0.5–1.0% over 3 months.
Prioritise protein and healthy fats at each meal — these slow glucose absorption and reduce post-meal spikes.
Eat in a consistent window — time-restricted eating (eating within an 8–10 hour window) has shown promise in reducing HbA1c in several recent RCTs, independent of calorie intake.
Increase dietary fibre — soluble fibre (oats, legumes, apples) slows glucose absorption. Aim for at least 25–30g per day.
Physical activity
Resistance training is particularly effective — building muscle increases the body's capacity to take up glucose from the bloodstream. Two to three sessions per week can lower HbA1c by 0.3–0.5%.
Walking after meals — even a 10–15 minute walk after eating has been shown to blunt post-meal glucose spikes more effectively than a single longer walk at another time of day.
Aim for 150+ minutes of moderate activity per week — this is the minimum threshold endorsed by both the ADA and NICE for metabolic health.
Sleep and stress
Chronic sleep deprivation (less than 6 hours) elevates cortisol, which in turn raises blood glucose. Prioritising sleep quality is a legitimate metabolic intervention.
Psychological stress raises cortisol and can meaningfully worsen HbA1c — particularly in people who are already metabolically vulnerable.
✅ Tip
HbA1c changes slowly. Don't expect big movements after just 6 weeks of change — meaningful reductions typically take 3 months to appear in your results. Track it every 3 months while making changes, so you can see the trend clearly.
How often should you test?
For people without diabetes or risk factors, testing HbA1c once a year as part of a routine health screen is appropriate. But if your reading has come back elevated, here's a more useful cadence:
Situation
Recommended frequency
Normal result, no risk factors
Every 1–3 years
Prediabetes range
Every 3–6 months (while making changes)
Diabetes, well-controlled
Every 6 months
Diabetes, poorly controlled or newly diagnosed
Every 3 months
Know what your HbA1c means for you
Upload your full blood panel and VitalMetrics AI will put your HbA1c in context — cross-referencing it with your fasting glucose, lipid profile, and other markers to give you a complete metabolic picture.
Medical disclaimer: This article is for informational purposes only and does not constitute medical advice, diagnosis, or treatment. HbA1c results should always be interpreted in the context of your full clinical picture by a qualified healthcare professional. If your result is in the prediabetes or diabetic range, please consult your GP or a diabetes specialist.